| 2003 | Dug It Up & Hott | Fanciulli & Knight | 1 |
| 2003 | Tonight | Mark Knight | 1 |
| 2004 | We Got Tha | ATFC & Mark Knight | 1 |
| 2004 | Desire | ATFC & Mark Knight Presents Tracer | 1 |
| 2004 | Non Stop Rock | Mark Knight | 1 |
| 2005 | A New Reality | Mark Knight & Martijn ten Velden | 1 |
| 2006 | This Is Jack / Astral Acid | Harris & Knight | 1 |
| 2006 | The Reason | Mark Knight feat. The B.B.n. | 3 |
| 2006 | A New Reality (Remixes) | Mark Knight & Martijn ten Velden | 1 |
| 2007 | Drug Music (Remixes) | Mark Knight | 1 |
| 2007 | Colombian Soul EP (Remixes) | D.Ramirez & Mark Knight | 1 |
| 2007 | I Like That | Mark Knight | 1 |
| 2007 | Just Trippin / The Reason | Fedde Le Grand Feat. Mc Gee / Mark Knight Feat. The B.B.N | 1 |
| 2008 | Shogun | Mark Knight & Funkagenda | 1 |
| 2008 | Man With the Red Face | Mark Knight & Funkagenda | 8 |
| 2008 | Susan | Mark Knight Feat Stephen Pickup | 1 |
| 2008 | From the Speaker | Mark Knight & Adam K & Soha | 1 |
| 2009 | Downpipe | Mark Knight & D. Ramirez vs. Underworld | 4 |
| 2009 | Put Your Hands Up | Mark Knight vs. Koen Groeneveld | 1 |
| 2009 | Good Times | Seamus Haji v Mark Knight & Funkagenda | 2 |
| 2010 | Stopover | Dirty South & Mark Knight | 1 |
| 2010 | Antidote | Mark Knight & Funkagenda | 1 |
| 2010 | Bullets Vol. 1 | Mark Knight | 2 |
| 2010 | Conscindo | Mark Knight & Wolfgang Gartner | 1 |
| 2011 | Beautiful World | Tiësto & Mark Knight feat. Dino | 5 |
| 2012 | Nothing Matters | Mark Knight featuring Skin | 4 |
| 2013 | Ten | Sander van Doorn & Mark Knight V Underworld | 1 |
| 2013 | Your Love | Mark Knight | 1 |
| 2014 | The Return of Wolfy | Mark Knight | 2 |
| 2015 | Ironing Man / Feel Good Now | Mark Knight | 1 |
| 2015 | Second Story | Mark Knight | 1 |
| 2015 | Dance On My Heart | Mark Knight & Adrian Hour Feat. Indiana | 1 |
| 2016 | Voulez-Who? | Mark Knight | 1 |
| 2016 | Yebisah | Mark Knight | 1 |
| 2017 | Live Stream | Mark Knight, Green Velvet & Rene Amesz | 4 |
| 2017 | Move On / Let Me Go | Mark Knight & Ben Remember | 1 |
| 2017 | Jus' Come | Mark Knight & Tuff London | 1 |
| 2018 | We Get High From The Music | Mark Knight feat. Mr. V | 1 |
| 2019 | The General | Mark Knight | 1 |
| 2019 | Something About U | Mark Knight vs. Mr Roy | 1 |
| 2020 | If It’s Love | Mark Knight feat. Laura Davie & The Melody Men | 1 |
| 2020 | Colombian Soul (Sllash & Doppe Remix) | D. Ramirez & Mark Knight | 1 |
| 2020 | Don’t Give Up | Mark Knight & Tuff London | 1 |
| 2020 | All 4 Love | Mark Knight & René Amesz feat. Tasty Lopez | 2 |
| 2021 | Everything's Gonna Be Alright | Mark Knight & Beverley Knight Feat. London Community Gospel Choir | 1 |
| 2021 | You Saw Me | Mark Knight feat. Damon Trueitt | 1 |
| 2021 | Get This Feeling | Mark Knight & Darius Syrossian Feat. Prospect Park | 1 |
| 2022 | The Music Began To Play | Mark Knight & Armand van Helden | 2 |
| 2023 | Down to Earth | Armand van Helden & Mark Knight | 1 |
| 2023 | I Wanna Be Your Lover | Mark Knight, Sgt. Slick & Beverley Knight | 1 |
| 2023 | Lady (Hear Me Tonight) | Mark Knight & James Hurr | 1 |
| 2023 | Release Me | Mark Knight & Armand van Helden | 4 |
| 2024 | Don't Abuse It | Armand van Helden & Mark Knight | 1 |
| 2024 | I Got All This Love | Mark Knight, Darius Syrossian & James Hurr | 1 |
| 2024 | Do It Y’all | Grant Nelson & Mark Knight | 1 |
| 2024 | Go Deep | James Haskell, Mark Knight & Gene Farris | 1 |
| 2025 | Fighting Love | Mark Knight & Mark Dedross | 1 |
| 2025 | Get Deep | Roland Clark, Mark Knight, James Hurr | 1 |
| 2025 | Televised (Extended Mix) | Mark Knight , Roland Clark | 1 |
